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Study the following carefully and explai...

Study the following carefully and explain why mutation (A) did not cuase any sickle cell anemia inspite of change in the molecular structure of the gene which codes for haemoglobin ,when as a similar mutation (B)did. (The question is based on properties of the genetic code.c=codon,a=amino acid ,Hb= Haemoglobin)
Amino acids in Hb:`a_(1)-a_(2)-a_(3)-a_(4)-a_(5)`-Glutamic acid-Glutamic acid-`a-(8)`...............
(Normal Haemoglobin)
Mutation (A): `C_(1)-C_(2)-C_(3)-C_(4)-C_(5)-GAA-GAA-C_(8)`......................
`a_(1)-a_(2)-a_(3)-a_(4)-a_(5)`-Glutamic acid-Glutamic acid-`a_(8)`..............
(Normal haemoglobin)
Mutation (B): `C_(1)-C_(2)-C_(3)-C_(4)-C_(5)`-GUG-GAA-`C_(8)`...................
`a_(1)-a_(2)-a_(3)-a_(4)-a_(5)`-valine-Glutamic acid-`a_(8)`.............
(Sickle cell Haemoglobin)

Text Solution

AI Generated Solution

To understand why mutation (A) did not cause sickle cell anemia while mutation (B) did, we need to analyze the changes in the genetic code and their effects on the amino acid sequence of hemoglobin. ### Step-by-Step Solution: 1. **Understanding Normal Hemoglobin Structure**: - Normal hemoglobin consists of a sequence of amino acids. In the provided sequence, the 6th position is occupied by glutamic acid, which is coded by the codons GAG or GAA. 2. **Analyzing Mutation (A)**: ...
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