Urea cycle operates in ………..

Explanation

**Step-by-Step Solution:**

1. **Understanding the Urea Cycle**: The urea cycle is a series of biochemical reactions that convert ammonia, which is toxic, into urea, which is less toxic and can be excreted from the body.

2. **Location of the Urea Cycle**: The urea cycle primarily operates in the liver. This is because the liver contains specialized cells called hepatocytes that are responsible for carrying out the reactions of the urea cycle.

3. **Role of Hepatocytes**: Hepatocytes make up about 80% of the liver's mass and contain the necessary enzymes to facilitate the conversion of ammonia into urea.

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