The major cause of ozone layer destruction is the release of freons in the atmosphere.

Answer

### Step-by-Step Solution:

1. **Understanding the Ozone Layer**: The ozone layer is a region of Earth's stratosphere that contains a high concentration of ozone (O₃) molecules. It plays a crucial role in protecting life on Earth by absorbing the majority of the sun's harmful ultraviolet (UV) radiation.

2. **Identifying the Cause of Ozone Depletion**: The primary cause of ozone layer depletion is the release of chlorofluorocarbons (CFCs), commonly referred to as freons. These compounds are used in various applications, including refrigeration, air conditioning, and aerosol propellants.

3. **Chemical Composition of CFCs**: CFCs are composed of carbon (C), chlorine (Cl), and fluorine (F). The presence of chlorine in these compounds is particularly significant because chlorine atoms are released into the atmosphere when CFCs break down.

4. **Mechanism of Ozone Depletion**: Once released into the atmosphere, chlorine atoms can react with ozone (O₃) molecules. A single chlorine atom can destroy thousands of ozone molecules before it is removed from the stratosphere. The reaction can be summarized as follows:
- Cl + O₃ → ClO + O₂
- ClO + O → Cl + O₂
This cycle continues, leading to the depletion of the ozone layer.

5. **Conclusion**: Given the information, it is clear that the statement "The major cause of ozone layer destruction is the release of freons in the atmosphere" is true. The release of CFCs (freons) leads to the release of chlorine atoms, which significantly contribute to the depletion of the ozone layer.