Mendelian Disorder

Principle OF Inheritance and Variations : Pleiotropy, Chromosomal Theory OF Inheritance, Sex Determination, Experimental Genetics T.H Morgan Drosophila, Melanogaster. Mutations, Genetic Disorder 1.Chromosomal Disorders 2.Mendelian Disorders

Assertion: Mendelian disorders are transmitted to offspring on the same lines as in the principles of inheritance. Reason: The pattern of inheritance of Mendelian disorders cannot be traced in a family by the pedigree analysis.

Why are thalassemia and hemophilia categorized as Mendelian disorders ? Write the symptoms of these diseases .Explain their pattern of inheritance in humans. ( b) Write the genotypes of the normal parents producing a heamophilic son.

Read the following statemenets and choose the correct option I. Failure of segregation of chromatids duringt cell division results in aneuploidy (II) Chromposomal disorders are maninly determined buy alteration or mutation in a single gene (III) Thalassemia and cystic fibrosis are Mendelian disorders (IV) Sickle cell anameia is an X- linked trait ltbvrgt (V) Haemophilia is an autosome linked recessive disease

Why are colourblindness and thalassemia categorized as Mendelian disorders ? Write the symptoms of these disease seen in people suffering from them. ( b) About 8 % of human male population suffers from colorblindness whereas only about 0.4% of human female population suffers from this disease .Write an explanation to show how it is possible

Given below is the representation of a relevant part of amino acid composition of the beta -chain of haemoglobin, related to the shape of human red blood cells. (a) Is this representation of the sequence of amino acids indicating a normal human or a sufferer from a certain blood related genetic disease ? Give reason in support of your answer. (b) Why is the disease referred to as a Mendelian disorder ? Explain.

Genetic Disorder:-Mendalian Disorder |Chromosomal Disorder |OMR