Mark the incorrect statement in context to `O_(2)` binding to Hb:

Options

A. Higher ph
B. Lower temperature
C. Lower `P_(co_(2))`
D. Higher `P_(o_(2))`

Answer

To determine the incorrect statement in the context of oxygen (O₂) binding to hemoglobin (Hb), we need to analyze each option given in the question based on the physiological principles of gas exchange and hemoglobin function.

### Step-by-Step Solution:

1. **Understanding Hemoglobin and O₂ Binding**:
- Hemoglobin is a protein found in red blood cells that binds to oxygen molecules. The binding of oxygen to hemoglobin forms oxyhemoglobin.

2. **Factors Affecting O₂ Binding**:
- Several factors influence the binding of oxygen to hemoglobin, including:
- Partial pressure of oxygen (pO₂)
- Partial pressure of carbon dioxide (pCO₂)
- Temperature
- Concentration of hydrogen ions (H⁺)

3. **Analyzing the Options**:
- **Option A: Higher H⁺ concentration**:
- A higher concentration of H⁺ ions (lower pH) leads to a decrease in the affinity of hemoglobin for oxygen. This means that higher H⁺ concentration does not favor the binding of oxygen to hemoglobin.
- **Option B: Lower temperature**:
- Lower temperatures increase the affinity of hemoglobin for oxygen, thus supporting the formation of oxyhemoglobin.
- **Option C: Lower pCO₂**:
- A lower partial pressure of carbon dioxide favors the binding of oxygen to hemoglobin, thus supporting the formation of oxyhemoglobin.
- **Option D: Higher pO₂**:
- A higher partial pressure of oxygen increases the binding of oxygen to hemoglobin, supporting the formation of oxyhemoglobin.

4. **Identifying the Incorrect Statement**:
- Based on the analysis:
- Option A is the incorrect statement because higher H⁺ concentration does not support the binding of oxygen to hemoglobin.

### Final Answer:
The incorrect statement in context to O₂ binding to hemoglobin is **Option A: Higher H⁺ concentration**.