Distinguish between prosthetic group and coenzyme.

Explanation

### Step-by-Step Solution:

1. **Definition of Enzymes**: Enzymes are biological catalysts made primarily of protein chains. They often require non-protein components to become catalytically active.

2. **Role of Cofactors**: Non-protein parts that assist enzymes in becoming active are known as cofactors. These cofactors can be classified into three types: prosthetic groups, coenzymes, and metal ions.

3. **Prosthetic Groups**:
- Prosthetic groups are organic compounds that are **tightly bound** to the active site of enzymes.
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