Coenzymes :
(1) Act as a donor of groups of atoms added to the substrate
(2) Act as acceptor of groups of atom removed from substrate
(3) Cannot be easily separated from apoenzyme
(4) Do not act as prosthetic groups Codes:

Options

A. 1 , 2 and 3 correct
B. 1 and 2 correct
C. 2 and 4 are correct
D. 1 and 3 are correct

Answer

To solve the question regarding coenzymes, we need to analyze each statement provided and determine their validity based on the characteristics of coenzymes.

### Step-by-Step Solution:

1. **Understanding Coenzymes**: Coenzymes are organic molecules that assist enzymes in catalyzing reactions. They are not proteins but are essential for the activity of certain enzymes.

2. **Analyzing Statement (1)**:
- **Statement**: Coenzymes act as a donor of groups of atoms added to the substrate.
- **Evaluation**: This statement is true. Coenzymes often donate functional groups to substrates during enzymatic reactions.

3. **Analyzing Statement (2)**:
- **Statement**: Coenzymes act as acceptors of groups of atoms removed from the substrate.
- **Evaluation**: This statement is also true. Coenzymes can accept atoms or groups that are removed from the substrate, facilitating the reaction.

4. **Analyzing Statement (3)**:
- **Statement**: Coenzymes cannot be easily separated from the apoenzyme.
- **Evaluation**: This statement is false. Coenzymes are typically loosely associated with the apoenzyme (the protein part of the enzyme) and can be easily separated.

5. **Analyzing Statement (4)**:
- **Statement**: Coenzymes do not act as prosthetic groups.
- **Evaluation**: This statement is true. Prosthetic groups are tightly bound to the enzyme, while coenzymes are loosely attached.

6. **Conclusion**: Based on the evaluations:
- True statements: (1), (2), and (4)
- False statement: (3)

### Final Answer:
The correct codes for the statements that are true regarding coenzymes are **(1), (2), and (4)**.

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