Who proposed lock and key enzyme hypothesis of enzyme activity ?

Explanation

### Step-by-Step Solution:

1. **Understanding the Question**: The question asks for the individual who proposed the lock and key hypothesis of enzyme activity.

2. **Identifying the Hypothesis**: The lock and key hypothesis is a model that explains how enzymes interact with substrates. It suggests that the enzyme's active site (the lock) is specifically shaped to fit a particular substrate (the key).

3. **Historical Context**: The lock and key hypothesis was introduced in the context of enzyme activity to explain how enzymes catalyze biochemical reactions.

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