An enzyme is kept at -`10^@C` for 3 minutes and is used in a chemical reaction (P). It is then gradually brought to room temperature. It is now used in a chemical reaction (Q). Another enzyme is kept at `80^@C` For 5 minutes and is used in chemical reaction (R). It is then gradually brought to room temperature. It is now used in a chemical reaction (S). Which of these reactions will be catalyzed by enzyme and which will not?