Besides better aeration and mixing properties, what other advantages do stirred tank bioreactors have over shake flasks?

Explanation

### Step-by-Step Solution

1. **Introduction to Shake Flasks**: Shake flasks are commonly used in laboratory settings for small-scale mixing and growth of microbial cultures. They are suitable for initial experiments but have limitations when it comes to large-scale production.

2. **Need for Bioreactors**: For large-scale production of biotechnological products, bioreactors are essential. They provide a controlled environment that is necessary for optimal growth and production.

3. **Advantages of Stirred Tank Bioreactors**:
- **Periodic Sampling**: Bioreactors allow for the periodic withdrawal of small volumes of culture for sampling without disrupting the entire system. This is crucial for monitoring growth and product formation.
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