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How is a polypeptide chain synthesis ter...

How is a polypeptide chain synthesis terminated during protein synthesis?

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Synthesis of polypeptide chain terminates when a nonsense codon of mRNA reaches the A-site. There are three nonsense codon UAA, UAG and UGA, which are not recognized by any of the tRNAs. Therefore no more amino-acyl tRNA reaches the A site. The P site t-RNAs is hydrolysed and the completed polypeptide is released in the presence of GTP dependent release factor.
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After the addition of the last amino acid to a growing polypeptide chain during the process of protein synthesis, one of the termination codons reaches the appropriate site on the ribosomal surface and then the following envents take place (i) Release of t-RNA molecule from the ribosome. (ii) Dislodging of polypeptide chain from the t-RNA (iii) Dissociation of ribosomes into large and small subunits. ltBrgt The correct sequence of these events:

OSWAAL PUBLICATION-MOLECULAR BASIS OF INHERITANCE -TOPIC-2: Short Answer Type Question- I
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  4. Comment on the utility of variability in number of tandem repeats duri...

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  5. Give an account of mRNA.

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  6. Differentiate between Exons and Introns.

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  7. How is a polypeptide chain synthesis terminated during protein synthes...

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  8. What are structural genes? Name the three structural genes present in ...

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  9. What do you understand by UTR ? Mention its role in translation.

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  10. Enumerate the goals of human genome project.

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  11. Three codons on mRNA are not recognized by transfer RNA. What are they...

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  12. Why is it essential that tRNA binds to both an amino acid and an mRNA ...

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  13. What will these DNA codons be translated into TAC, AAA, ATC? (b) Wh...

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  15. Draw the structure of the initiator tRNA adaptor molecule.

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  16. Why is tRNA called an adaptor molecule?

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  17. One of the codons on mRNA is AUG. Draw the structure of tRNA adaptor m...

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  18. Explain the dual function of AUG codon. Give the sequence of bases it ...

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  19. How can DNA segments, separated by gel electrophoresis, be visualized ...

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  20. What is satellite DNA in a genome ? Explain their role in DNA fingerpr...

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