Which inactivates an enzyme by occupying its active site ?

Which one inactivates an enzyme by changing the enzyme shape ?

Which one inactivates an enzyme by changing the enzyme shape ?

Which one inactivates an enzyme by changing the enzyme shape ?

Which one inactivates an enzyme by changing the enzyme shape ?

Which of these inactivates an enzyme by changing enzyme shape?

Assertion (A) Non-competative inhibitor inhibits the catalytic activity of enzyme by binding with its active site. Reason (R) Non-competitive inhibitor changes the shape of the active site in such a way that substrate can't recognise it .

Assertion (A) Non-competative inhibitor inhibits the catalytic activity of enzyme by binding with its active site. Reason (R) Non-competitive inhibitor changes the shape of the active site in such a way that substrate can't recognise it .

Assertion (A) : Non-competitive inhibitor inhibits the catalytic activity of enzyme by binding with its active site. Reason (R): Non-competitive inhibitor changes the shape of the active site in such a way that substrate can't recognise it