ELISA technique is based on the principle of antigen-antibody interaction. Can this technique be used in the molecular diagnosis of a genetic disorder, such as phenylketonuria?

Explanation

**Step-by-Step Solution:**

1. **Understanding ELISA**: The ELISA (Enzyme-Linked Immunosorbent Assay) technique is based on the principle of antigen-antibody interaction. It is primarily used to detect the presence of specific proteins (antigens) in a sample by using antibodies that specifically bind to those proteins.

2. **Phenylketonuria (PKU)**: Phenylketonuria is a genetic disorder caused by the inability of the body to metabolize phenylalanine due to a deficiency of the enzyme phenylalanine hydroxylase. This leads to the accumulation of phenylalanine in the body, which can cause serious health issues if not managed.

3. **Application of ELISA in PKU Diagnosis**: While ELISA is typically used to detect proteins or antibodies, it can be adapted for genetic disorders like PKU. In the case of PKU, the absence of the enzyme (which is a protein) can be detected using ELISA.

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