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Calcium ion concentration in blood affec...

Calcium ion concentration in blood affects muscle contraction. Does it lead to tetany in certain cases? How will you correlate fluctuation in blood calcium with tetany?

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### Step-by-Step Solution: 1. **Understanding Muscle Contraction**: Muscle contraction requires the binding of myosin to actin filaments. For this to happen, the binding sites on the actin filaments must be uncovered. 2. **Role of Calcium Ions**: Calcium ions play a crucial role in muscle contraction. When calcium ions are present in the cytosol, they bind to the troponin complex, which is a regulatory protein associated with the thin filament (actin). 3. **Troponin and Tropomyosin Interaction**: The binding of calcium to troponin causes a conformational change that moves tropomyosin away from the myosin binding sites on actin. This exposure allows myosin heads to attach to actin, leading to muscle contraction. ...
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The steps involved in the mechanism of muscle contraction are given below. Arrange the steps in proper sequential order and select the correct option. I. Release of calcium ions in the sarcoplasm. II. Signal sent by the CNS via a motor neuron. III. Binding of calcium with a subunit of troponin on actin filaments. IV. Generation of the action potential in the sarcolemma. V. Binding of myosin head to the exposed active sites on actin to form a cross-bridge. VI. Inward pulling of ‘Z’ line attached to actin causing shortening of the sarcomere. VII. Pulling of the attached actin filaments towards the centre of 'A' band. VIII. Release of neurotransmitter acetylcholine and generation of the action potential in the sarcolemma.

Assertion: Tetany is rapid spasm in muscle. Reason: Tetany is usually caused by an increases in the blood calcium level.