Recell the experiments done by frederick Griffith, Avery, MacLeod and McCarty, where DNA was speculated to be the genatic material. If RNA , instead of DNA was the genetic meterial, would the heat killed strain of pneumoccus have transformed the R-strain into virulent strani? Explain.

Explanation

### Step-by-Step Text Solution

1. **Introduction to Griffith's Experiment**:
- Frederick Griffith conducted experiments in 1928 with two strains of *Streptococcus pneumoniae*: the virulent S strain (smooth) and the non-virulent R strain (rough). He discovered that when he injected mice with a mixture of heat-killed S strain and live R strain, the mice developed pneumonia and died. This indicated that some "transforming principle" from the dead S strain transformed the R strain into a virulent form.

2. **Avery, MacLeod, and McCarty's Experiment**:
- In 1944, Avery, MacLeod, and McCarty built upon Griffith's work. They isolated the transforming principle from the heat-killed S strain and identified it as DNA. They demonstrated that when DNA was destroyed by enzymes (DNase), the transformation did not occur, confirming that DNA was the genetic material responsible for the transformation of the R strain into the virulent S strain.

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