Which of the following will react with `CHCl_3+alc`. KOH ?

Options

A. Adenine and lysine
B. Thymine and proline
C. Adenine and thymine
D. Adenine and proline

Answer

To determine which of the following compounds will react with chloroform (CHCl3) and alcoholic KOH, we need to understand the carbylamine reaction. This reaction is specific to primary amines, which react with chloroform in the presence of alcoholic KOH to form isocyanides.

### Step-by-Step Solution:

1. **Identify the Reaction**: The carbylamine reaction involves the reaction of chloroform (CHCl3) with primary amines in the presence of alcoholic KOH. The general reaction can be represented as:
\[ RNH_2 + CHCl_3 + 3 KOH \rightarrow R-N \equiv C + 3 KCl + 3 H_2O \]
Here, RNH2 is a primary amine, and the product is an isocyanide (R-N≡C).

2. **Determine the Nature of Amines**: We need to check the structures of the given compounds to identify which ones contain primary amine groups. The options provided are likely to include nucleobases and amino acids.

3. **Analyze Each Compound**:
- **Adenine**: Contains an NH2 group (primary amine).
- **Lysine**: Contains two NH2 groups (both are primary amines).
- **Thymine**: Contains secondary amines (no primary amine).
- **Proline**: Contains a secondary amine (no primary amine).

4. **Conclusion**: Since the carbylamine reaction only occurs with primary amines, we conclude that adenine and lysine will react with chloroform and alcoholic KOH.

5. **Final Answer**: The correct answer is that both **adenine and lysine** will react with CHCl3 + alc. KOH.