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Thalassemia and haemophilia categorised ...

Thalassemia and haemophilia categorised as Mendelian disorders.

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Thalassemia and haemophilia are categorised as Mendelian disorders because these disorders are due to alteration in a single gene. Also they are transmitted to offsprings through Mendelian principles of inheritance.
= Symptoms and pattern of inheritance are given below:
= (a) Thalassemia : It is an autosomal linked recessive blood disorder characterised by defects in `alpha , beta or delta `chain resulting in abnormal Hb molecule.
= Symptom : Anaemia
= Inheritance : Two mutant alleles (one from each parent) must be inherited for an individual to be affected i.e. homozygous. Heterozygous are carriers and may pass the mutant allele to children.
= (b) Haemophilia : It is a sex linked recessive disorder whose gene is located on X-chromosome.
= Symptom : Prolonged clotting time and external bleeding even in minor injury.
= Inheritance : The gene is present on X-chromosome, so it is inherited by males as they have single X-chromosome. Affected males are said to be hemizygous. Females have two X-chromosomes, thus possibility of them being affected is rare as the mother of such female has to be atleast carrier and father should be haemophilic.
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KUMAR PRAKASHAN-PRINCIPLES OF INHERITANCE AND VARIATION -SECTION -F (MULTIPLE CHOICE QUESTIONS (MCQS)) (MCQs ASKED IN COMPETITIVE EXAM)
  1. Thalassemia and haemophilia categorised as Mendelian disorders.

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  2. The incorrect statement with regard to haemophilia is

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  3. Which Mendelian idea is depicted by a cross in which the F1-generation...

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  4. If both parents are carriers for thalassaemia, which is an autosomal r...

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  5. If two persons with .AB. blood group marry and have sufficiently large...

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  6. Which of the following statements is not true of two genes that show 5...

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  7. Fruit colour in squash is an example of

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  8. A human female with Tunner,s syndrome :-

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  9. A man whose father was colour blind marries a woman, who had a colour ...

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  10. what is pleiotropic gene ?

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  11. In his classic experiments on pea plants, Mendel did not use

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  12. A colourblind man marries a woman with normal sight who has no history...

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  13. In the following human pedigree, the filled symbols represent the affe...

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  14. The term "linkage" was coined by

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  15. A gene showing codominance has

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  16. The mechanism that causes a gene to move from one linkage group to ano...

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  17. what is true breeding line?

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  18. If a colourblind man marries a woman who is homozygous for normal colo...

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  19. A tall true breeding garden pea plant is crossed with a dwarf true bre...

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  20. Pick out the correct statements. I. Haemophilia is a sex-linked rece...

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  21. In a test cross involving F1 dihybrid flies, more parental-type offspr...

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