Select the incorrect statement from the following.

Options

A. Prosthetic groups are inorganic compounds which tightly bind with the apoenzyme.
B. Coenzymes are organic compounds but their association with apoenzyme is only transient.
C. Coenzymes serve as co-factors in number of enzyme catalysed reactions.
D. All of these

Explanation

To solve the question, let's analyze each statement one by one to identify the incorrect one.

### Step-by-Step Solution:

1. **Statement 1**: "Prosthetic groups are inorganic compounds which tightly bind with the apoenzyme."
- **Analysis**: Prosthetic groups can be either inorganic or organic. They are not purely inorganic. Additionally, prosthetic groups are typically tightly bound to the enzyme, not loosely. However, the statement incorrectly suggests that they are only inorganic and that they tightly bind, which is misleading.
- **Conclusion**: This statement is incorrect.

2. **Statement 2**: "Coenzymes are organic compounds but their association with apoenzyme is only transient."
- **Analysis**: Coenzymes are indeed organic compounds (often derived from vitamins) and their association with the enzyme (apoenzyme) is temporary or transient, meaning they bind and release during the enzymatic reaction.
- **Conclusion**: This statement is correct.

3. **Statement 3**: "Coenzymes serve as cofactors in a number of enzyme-catalyzed reactions."
- **Analysis**: Coenzymes do serve as cofactors, which are non-protein components that assist enzymes in catalyzing reactions. This statement accurately describes the role of coenzymes.
- **Conclusion**: This statement is correct.

### Final Conclusion:
The incorrect statement is the first one: "Prosthetic groups are inorganic compounds which tightly bind with the apoenzyme."