Which of the following is correct for the origin of lysosome (L) ?

Options

A. ER `rarr` Golgi bodies `rarr` L
B. Golgi bodies `rarr` ER `rarr` L
C. Nucleus `rarr` Golgi bodies `rarr` L
D. Mitochondria `rarr` ER `rarr` Golgi bodies `rarr` L

Answer

To determine the correct origin of lysosomes, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Lysosomes**:
- Lysosomes are membrane-bound organelles that contain hydrolytic enzymes responsible for breaking down various biomolecules such as proteins, lipids, carbohydrates, and nucleic acids.

2. **Biogenesis of Lysosomes**:
- The formation of lysosomes involves the synthesis of hydrolytic enzymes and membrane proteins. These components are crucial for the function of lysosomes.

3. **Role of Endoplasmic Reticulum (ER)**:
- The rough endoplasmic reticulum (RER) is where the synthesis of proteins occurs, including the hydrolytic enzymes needed for lysosomes. The RER is called "rough" because it has ribosomes attached to its surface.

4. **Transport to Golgi Apparatus**:
- Once the proteins are synthesized in the RER, they are packaged into transport vesicles. These vesicles then move to the Golgi apparatus.

5. **Golgi Apparatus Function**:
- The Golgi apparatus has two sides: the cis face (receiving side) and the trans face (shipping side). The vesicles from the RER fuse with the cis face of the Golgi apparatus, where they undergo further processing.

6. **Formation of Lysosomes**:
- After processing in the Golgi apparatus, the enzymes are packaged into new vesicles that bud off from the trans face of the Golgi apparatus. These vesicles are now known as lysosomes.

7. **Conclusion**:
- The correct sequence for the origin of lysosomes is:
- Endoplasmic Reticulum → Golgi Apparatus → Lysosomes.
- Therefore, the correct answer is **Option A**: Endoplasmic reticulum, Golgi bodies, lysosomes.