In which stage DNA replication takes place ?

Options

A. Metaphase
B. `G_(1)` phase
C. S-phase
D. `G_(2)` phase

Explanation

**Step-by-Step Solution:**

1. **Understanding the Cell Cycle**: The cell cycle consists of several stages, including interphase and mitotic phase. Interphase is further divided into G1 phase, S phase, and G2 phase.

2. **Identifying the Stages**:
- G1 Phase (Gap 1): This is the first stage of interphase where the cell grows and prepares for DNA replication.
- S Phase (Synthesis): This is the stage where DNA replication occurs. The DNA is synthesized, resulting in the duplication of the genetic material.
- G2 Phase (Gap 2): This is the final stage of interphase where the cell continues to grow and prepares for mitosis.

3. **Focusing on the S Phase**: During the S phase, the DNA content of the cell doubles. For example, if a cell has 2 picograms of DNA before the S phase, it will have 4 picograms after replication. However, the number of chromosomes remains the same; they are simply duplicated.

4. **Conclusion**: The stage in which DNA replication takes place is the S phase of interphase. Therefore, the correct answer to the question is the S phase.

**Final Answer**: DNA replication takes place in the S phase.

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