Select the incorrect statement regarding S phase of interphase.

Options

A. It occurs between `G_(1)` and `G_(2)`
B. DNA replicates in the nucleus in this phase.
C. Centrioles duplicate in the cytoplasm.
D. As DNA doubled, number of chromosomes also doubles.

Explanation

To solve the question regarding the incorrect statement about the S phase of interphase, we will analyze each statement one by one.

### Step-by-Step Solution:

1. **Understanding the S Phase**: The S phase, or synthesis phase, is a part of interphase where DNA replication occurs. It is crucial to know where this phase fits in the cell cycle.

2. **Analyzing Statement 1**: "It occurs between G1 and G2."
- **Evaluation**: This statement is correct. The cell cycle consists of G1 (Gap 1), S (Synthesis), and G2 (Gap 2) phases. The S phase indeed occurs between G1 and G2.

3. **Analyzing Statement 2**: "DNA replicates in the nucleus of the cell."
- **Evaluation**: This statement is also correct. In eukaryotic cells, DNA replication occurs in the nucleus, where the genetic material is housed.

4. **Analyzing Statement 3**: "Centrioles duplicate in the cytoplasm."
- **Evaluation**: This statement is correct as well. Centrioles, which are involved in cell division, are located in the cytoplasm and duplicate there during the S phase.

5. **Analyzing Statement 4**: "As the DNA doubles, the number of chromosomes also doubles."
- **Evaluation**: This statement is incorrect. During the S phase, the amount of DNA doubles, but the number of chromosomes remains the same. Each chromosome is replicated to form two sister chromatids, but they are still counted as one chromosome until they separate during mitosis.

### Conclusion:
The incorrect statement regarding the S phase of interphase is:
**"As the DNA doubles, the number of chromosomes also doubles."**