Which of the following statements is not correct regarding colchicine?

Options

A. It prevents assembly of microtubules.
B. It inhibits chromosome replication.
C. It is an alkaloid.
D. It is called as mitotic poison.

Explanation

To determine which statement is not correct regarding colchicine, let's analyze each option step by step.

1. **Understanding Colchicine**:
- Colchicine is a chemical compound that is classified as an alkaloid. It is derived from the plant Colchicum autumnale (autumn crocus).
- It is primarily known for its role in plant breeding and is used to induce polyploidy by doubling the number of chromosomes.

**Hint**: Remember that colchicine is an alkaloid and is associated with chromosome manipulation.

2. **Function of Colchicine**:
- Colchicine works by preventing the assembly of microtubules, which are crucial for the formation of the spindle apparatus during cell division.
- By interfering with microtubule formation, colchicine effectively arrests the cell cycle at the metaphase stage, preventing proper chromosome segregation.

**Hint**: Focus on how colchicine affects microtubules and cell division.

3. **Analyzing the Statements**:
- **Statement 1**: "It prevents assembly of microtubules."
- This is correct. Colchicine disrupts microtubule formation.
- **Statement 2**: "It inhibits chromosome replication."
- This is not correct. Colchicine does not inhibit the replication of chromosomes; instead, it interrupts spindle formation, which affects the distribution of chromosomes during cell division.
- **Statement 3**: "It is an alkaloid."
- This is correct. Colchicine is indeed classified as an alkaloid.
- **Statement 4**: "It is called a mitotic poison."
- This is also correct. Colchicine is referred to as a mitotic poison due to its ability to disrupt mitosis.

4. **Conclusion**:
- The statement that is not correct regarding colchicine is: "It inhibits chromosome replication."

**Final Answer**: The correct answer is that the statement "It inhibits chromosome replication" is not correct regarding colchicine.