Splitting of centromere and hence separation of chromatids occur during

Options

A. anaphase of mitosis
B. anaphase of meiosis I
C. anaphase of meiosis II
D. Both a and c

Answer

To answer the question regarding the splitting of the centromere and the subsequent separation of chromatids, we can break down the solution into the following steps:

### Step-by-Step Solution:

1. **Understanding Cell Division**:
- There are two main types of cell division: mitosis and meiosis. Mitosis maintains the chromosome number, while meiosis reduces it by half.

2. **Phases of Mitosis**:
- Mitosis consists of four phases: prophase, metaphase, anaphase, and telophase. During these phases, the chromosomes undergo specific changes.

3. **Anaphase of Mitosis**:
- During anaphase of mitosis, the centromeres split. This splitting is crucial because it allows the sister chromatids, which are identical copies of a chromosome, to separate and move towards opposite poles of the cell.

4. **Phases of Meiosis**:
- Meiosis also consists of two rounds: meiosis I and meiosis II, each having its own four phases (prophase, metaphase, anaphase, and telophase).

5. **Anaphase of Meiosis I**:
- In anaphase I of meiosis, the homologous chromosomes separate, but the centromeres do not split. Therefore, the sister chromatids remain attached.

6. **Anaphase of Meiosis II**:
- In anaphase II of meiosis, similar to mitosis, the centromeres split, allowing the sister chromatids to separate and move to opposite poles.

7. **Conclusion**:
- The splitting of the centromere and separation of chromatids occurs during the anaphase of mitosis and the anaphase of meiosis II. Therefore, the correct answer is both A (anaphase of mitosis) and C (anaphase of meiosis II).

### Final Answer:
The splitting of the centromere and hence separation of chromatids occurs during:
- Anaphase of Mitosis (A)
- Anaphase of Meiosis II (C)
Thus, the correct answer is both A and C.

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