Select the correct statement about `G_(1)` phase.

Options

A. Cell is metabolically inactive.
B. DNA in the cell does not replicate.
C. It is not a phase of synthesis of macromolecules.
D. Cell stops growing.

Explanation

### Step-by-Step Solution:

1. **Understanding the Cell Cycle**: The cell cycle consists of two main phases: interphase and the M phase (mitosis). Interphase is further divided into three phases: G1, S, and G2.

2. **Identifying the G1 Phase**: The G1 phase is the first phase of interphase. It is characterized by cell growth and preparation for DNA replication.

3. **Activities in the G1 Phase**:
- **Cell Growth**: During G1, the cell increases in size and synthesizes various proteins and organelles.
- **Metabolic Activity**: The cell is metabolically active, meaning it is engaged in various biochemical processes.
- **Preparation for DNA Replication**: The cell prepares for DNA replication by synthesizing nucleotides and ATP, which are essential for the upcoming S phase.

4. **DNA Replication**: It is important to note that DNA replication does not occur during the G1 phase; it occurs in the S phase. Therefore, any statement claiming that DNA replicates during G1 is incorrect.

5. **Evaluating Statements**:
- **Statement 1**: "The cell is metabolically inactive." - This is false; the cell is metabolically active in G1.
- **Statement 2**: "DNA in the cell does not replicate." - This is true; DNA replication occurs in the S phase.
- **Statement 3**: "It is not a phase of synthesis of macromolecules." - This is false; macromolecules like ATP and nucleotides are synthesized in G1.
- **Statement 4**: "Cell stops growing." - This is false; the cell is actively growing in G1.

6. **Conclusion**: The correct statement about the G1 phase is that "DNA in the cell does not replicate," which is true because DNA replication occurs in the S phase.