Refer to the given reaction
`alpha`-Ketoglutaric acid `+NH_(4)^(+)+NADPHunderset("dehydrogenase")overset("Glutamate")to"Glutamate"+H_(2)O+NADP` is represents

Options

A. oxidative amination
B. reductive amination
C. transamination
D. deamination

Explanation

To solve the question regarding the reaction of α-Ketoglutaric acid with NH4+ and NADPH to form Glutamate, we will analyze the components and the process involved in the reaction step by step.

### Step-by-Step Solution:

1. **Identify the Reactants and Products**:
- The reactants are α-Ketoglutaric acid, NH4+, and NADPH.
- The products are Glutamate, H2O, and NADP+.

2. **Understand the Role of Enzyme**:
- The enzyme involved in this reaction is Glutamate dehydrogenase. Dehydrogenases are enzymes that catalyze the removal of hydrogen from a substrate, which typically involves a reduction reaction.

3. **Analyze the Reaction Type**:
- The reaction involves the conversion of an acid (α-Ketoglutaric acid) into an amino acid (Glutamate) with the incorporation of an amino group (from NH4+).
- Since the reaction involves the addition of an amino group and the reduction of α-Ketoglutaric acid, it indicates that this is a reductive process.

4. **Define Reductive Amination**:
- Reductive amination is a process where an amine (in this case, NH4+) reacts with a carbonyl compound (α-Ketoglutaric acid) to form an amine (Glutamate) in the presence of a reducing agent (NADPH).
- Here, NADPH is used to reduce the carbonyl group of α-Ketoglutaric acid, facilitating the formation of Glutamate.

5. **Conclusion**:
- Therefore, the reaction represented is a **reductive amination**. The α-Ketoglutaric acid is reduced to form Glutamate, with the amino group being introduced from NH4+.

### Final Answer:
The reaction is a **reductive amination**.

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