In the clotting mechanism pathway, thromin activates the factors

Options

A. `XI,VIII,V`
B. `XI,IX,X`
C. `VIII,X,V`
D. `IX,VIII,X`

Explanation

**Step-by-Step Solution:**

1. **Understanding Thrombin's Role**: Thrombin is a key enzyme in the blood clotting process (hemostasis). It plays a crucial role in converting fibrinogen, a soluble plasma protein, into fibrin, which forms the meshwork of a blood clot.

2. **Identifying Activated Factors**: Thrombin also activates several pro-coagulant factors in the clotting cascade. The important factors that thrombin activates include Factor V, Factor VIII, Factor XI, and Factor XIII.

3. **Analyzing the Options**: We need to evaluate the given options to see which one includes the factors activated by thrombin:
- **Option 1**: 11th, 8th, 5th (Correct)
- **Option 2**: 11th, 9th, 10th (Incorrect)
- **Option 3**: 8th, 10th, 5th (Incorrect)
- **Option 4**: 9th, 8th, 10th (Incorrect)

4. **Conclusion**: The correct answer is **Option 1: 11th, 8th, 5th**, as these are the factors that thrombin activates in the clotting mechanism pathway.