What will happen if the secretion of parietal cells of gastric glands is blocked with an inhibitor?

Options

A. In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin.
B. Enterokinase will not be released from the duodenal mucosa and so trypsinogen is not converted to trypsin.
C. Gastric juice will be deficient in chymosin.
D. Gastric juice will be deficient in perpsinogen.

Explanation

### Step-by-Step Solution:

1. **Understanding Parietal Cells**:
- Parietal cells are specialized cells located in the gastric glands of the stomach. Their primary function is to secrete hydrochloric acid (HCl).

2. **Role of Hydrochloric Acid (HCl)**:
- HCl plays a crucial role in the digestive process. It not only creates an acidic environment in the stomach but also activates the enzyme pepsin from its inactive form, pepsinogen.

3. **Effect of Blocking Secretion**:
- If the secretion of parietal cells is inhibited, HCl will not be produced. This means that pepsinogen will remain in its inactive form and will not be converted into active pepsin.

4. **Consequences for Digestion**:
- Without active pepsin, the digestion of proteins will be severely impaired. Pepsin is essential for breaking down proteins into smaller peptides, a process known as proteolysis.

5. **Conclusion**:
- Therefore, if the secretion of parietal cells is blocked, the conversion of pepsinogen to pepsin will not occur, leading to ineffective protein digestion.

### Final Answer:
In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin, resulting in impaired protein digestion.

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