Enzyne collagenase breaks the peptide bonds present in collagen protein. Excessive seretion of this enzyme will lead to weakening of which of the following body parts ?
(i) Tendons
(ii) Bones
(iii) Hair shafts
(iv) Nails and claws
(v) Intervertebral discs

Options

A. (i),(ii) and (iii)
B. (i),(ii) and (v)
C. (iii) and (iv)
D. (ii),(iii) and (v)

Explanation

To solve the question regarding the effects of excessive secretion of the enzyme collagenase, we need to understand the role of collagen in various body parts and how collagenase affects it.

**Step 1: Understand the function of collagenase**
Collagenase is an enzyme that breaks down collagen by cleaving the peptide bonds in collagen proteins. Collagen is a crucial structural protein found in various connective tissues in the body.

**Hint:** Remember that collagenase specifically targets collagen, which is abundant in many connective tissues.

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**Step 2: Identify where collagen is found in the body**
Collagen is present in several body parts, including:
- Tendons
- Bones
- Intervertebral discs
- Cartilage
- Skin
- Blood vessels

**Hint:** Think about the structural roles of different body parts and where collagen might be necessary for strength and support.

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**Step 3: Analyze the options provided**
(i) Tendons - Tendons are made of dense connective tissue and are rich in collagen fibers.
(ii) Bones - Bones have collagen in their matrix, providing strength and flexibility.
(iii) Hair shafts - Hair is primarily made of keratin, not collagen.
(iv) Nails and claws - Like hair, nails and claws are made of keratin.
(v) Intervertebral discs - These discs contain fibrocartilage, which is rich in collagen fibers.

**Hint:** Focus on the options that are known to have a significant amount of collagen.

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**Step 4: Determine the impact of excessive collagenase secretion**
Excessive collagenase would lead to the breakdown of collagen in the identified structures. Therefore, the body parts that would weaken due to excessive collagenase secretion are:
- Tendons
- Bones
- Intervertebral discs

**Hint:** Consider which options contain collagen and how their structural integrity would be compromised if collagen were broken down excessively.

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**Step 5: Select the correct answer**
From the analysis, the body parts that would weaken due to excessive collagenase secretion are:
- Tendons (i)
- Bones (ii)
- Intervertebral discs (v)

Since the question asks for body parts that would weaken, the correct answer includes (i), (ii), and (v).

**Final Answer:** (i) Tendons, (ii) Bones, and (v) Intervertebral discs.

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