Select the wrong statements with respect to glycolysis.

Options

A. It occurs outside mitochondria
B. it an anaerobic phase
C. Glucose undergoes partial oxidation to form 2 molecules of pyruvic acid
D. Glucose is phosphorylates to glucose-6-phosphate by isomerase enzyme.

Explanation

**Step-by-Step Solution:**

1. **Understanding Glycolysis**: Glycolysis is a metabolic pathway that converts glucose into pyruvate, producing a small amount of energy in the form of ATP. It occurs in the cytoplasm of the cell and does not require oxygen, making it an anaerobic process.

2. **Analyzing Each Statement**:
- **Statement 1**: "It occurs outside the mitochondria."
- This statement is **correct** because glycolysis takes place in the cytoplasm, which is outside the mitochondria.

- **Statement 2**: "It is an anaerobic phase."
- This statement is also **correct**. Glycolysis can occur without oxygen, classifying it as anaerobic.

- **Statement 3**: "Glucose undergoes partial oxidation to form two molecules of pyruvic acid."
- This statement is **correct**. During glycolysis, one molecule of glucose is partially oxidized to produce two molecules of pyruvate.

- **Statement 4**: "Glucose is phosphorylated to glucose 6-phosphate by isomerase enzyme."
- This statement is **incorrect**. The phosphorylation of glucose to glucose-6-phosphate is catalyzed by the enzyme hexokinase, not an isomerase.

3. **Conclusion**: The only incorrect statement regarding glycolysis is **Statement 4**.

**Final Answer**: The wrong statement with respect to glycolysis is: "Glucose is phosphorylated to glucose 6-phosphate by isomerase enzyme."

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