Study the following statements regarding chemiosmotic hypothesis in mitochondria and select the correct ones.
(i) `F_(1)` headpiece contains the site for the synthesis of ATP from `ADP + Pi`.
(ii) `F_(0)` par forms the channel through which protons cross the inner membrane.
(iii) For each ATP produced, `2H^(+)` pass through `F_(0)` from the intermembrane space to the matrix down the electrochemical proton gradient.

Options

A. (i) and (ii)
B. (ii) and (iii)
C. (i) and (iii)
D. (i),(ii) and (iii)

Answer

To analyze the statements regarding the chemiosmotic hypothesis in mitochondria, we will evaluate each statement step by step.

### Step 1: Evaluate Statement (i)
**Statement:** F1 headpiece contains the site for the synthesis of ATP from ADP + Pi.

**Analysis:** The F1 portion of ATP synthase is indeed responsible for the synthesis of ATP. It contains the catalytic sites where ADP and inorganic phosphate (Pi) combine to form ATP. Therefore, this statement is **correct**.

### Step 2: Evaluate Statement (ii)
**Statement:** F0 particle forms the channel through which protons cross the inner membrane.

**Analysis:** The F0 component of ATP synthase is embedded in the inner mitochondrial membrane and forms a channel that allows protons (H⁺ ions) to flow from the intermembrane space into the mitochondrial matrix. This flow of protons is essential for ATP synthesis. Thus, this statement is also **correct**.

### Step 3: Evaluate Statement (iii)
**Statement:** For each ATP produced, 2H⁺ pass through F0 from the intermembrane space to the matrix down the electrochemical proton gradient.

**Analysis:** According to the chemiosmotic hypothesis, it is generally accepted that approximately 3.33 protons are required to synthesize one ATP molecule. However, the hypothesis simplifies this to state that 2 protons pass through the F0 channel for each ATP produced. Since the question specifically refers to the chemiosmotic hypothesis, this statement is considered **correct** in the context of the hypothesis.

### Conclusion
All three statements (i), (ii), and (iii) are correct in the context of the chemiosmotic hypothesis. Therefore, the correct answer is that all statements are correct.

### Final Answer
The correct options are: (i), (ii), and (iii) - all three statements are correct.

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