Phosphorylation of glucose during glycolysis is catalysed by

Options

A. phosphoglucomutase
B. phosphoglucoisomerase
C. hexokinase
D. phosphorylase

Explanation

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks about the enzyme that catalyzes the phosphorylation of glucose during glycolysis. Phosphorylation refers to the addition of a phosphate group to a molecule.

2. **Identifying the Process**: In glycolysis, glucose is converted into pyruvate. The first step of this process involves the phosphorylation of glucose to form glucose-6-phosphate.

3. **Enzyme Involvement**: The enzyme responsible for this phosphorylation is crucial. The options provided are:
- Phosphoglucomutase
- Phosphoglucoisomerase
- Hexokinase
- Phosphorylase

4. **Analyzing Each Option**:
- **Hexokinase**: This enzyme catalyzes the addition of a phosphate group to glucose, converting it into glucose-6-phosphate. This reaction consumes ATP, which donates the phosphate group.
- **Phosphoglucoisomerase**: This enzyme converts glucose-6-phosphate into fructose-6-phosphate, but does not catalyze phosphorylation.
- **Phosphoglucomutase**: This enzyme transfers a phosphate group within glucose molecules but does not catalyze the initial phosphorylation of glucose.
- **Phosphorylase**: This enzyme adds a phosphate group from inorganic phosphate to a substrate but is not involved in the phosphorylation of glucose in glycolysis.

5. **Conclusion**: Based on the analysis, the enzyme that catalyzes the phosphorylation of glucose during glycolysis is **Hexokinase**.

**Final Answer**: Hexokinase

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