In which stage of the cell cycle are histone proteins synthesised in a eukaryotic cells ?

Options

A. `G_(2)`- stage of prophase
B. S-phase
C. Entire prophase
D. Telophase

Answer

To determine the stage of the cell cycle in which histone proteins are synthesized in eukaryotic cells, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Histone Proteins**: Histone proteins are essential for the structural organization of DNA in eukaryotic cells. They help package the long strands of DNA into a compact form, allowing it to fit within the nucleus.

2. **Role of Histones**: Histones not only provide structural support but also play a role in gene regulation. They help in the formation of chromatin, which is the complex of DNA and proteins.

3. **Cell Cycle Overview**: The cell cycle consists of several phases: G1 (Gap 1), S (Synthesis), G2 (Gap 2), and M (Mitosis). Each phase has specific activities related to cell growth, DNA replication, and cell division.

4. **Focus on the S Phase**: The S phase, or Synthesis phase, is specifically designated for DNA replication. During this phase, the entire DNA content of the cell is duplicated in preparation for cell division.

5. **Synthesis of Histones**: Along with DNA replication in the S phase, histone proteins are synthesized. This is crucial because as the DNA is replicated, new histones are required to package the newly formed DNA strands into chromatin.

6. **Conclusion**: Therefore, histone proteins are synthesized during the S phase of the cell cycle.

### Final Answer:
Histone proteins are synthesized during the S phase of the cell cycle in eukaryotic cells.

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