Which of the following is synthesised in both the brain and endocrine glands?

Options

A. ACTH
B. Cortisol
C. Oxytocin
D. Somatostatin

Explanation

To determine which substance is synthesized in both the brain and endocrine glands, we can analyze each option provided:

1. **ACTH (Adrenocorticotropic Hormone)**:
- Synthesized in the anterior pituitary gland.
- It is not synthesized in the brain; it is a hormone that stimulates the adrenal glands.

2. **Cortisol**:
- Produced by the adrenal glands.
- It is not synthesized in the brain.

3. **Oxytocin**:
- Synthesized in the hypothalamus (part of the brain) and secreted by the posterior pituitary gland.
- However, it is primarily associated with the pituitary gland and not synthesized in other endocrine glands.

4. **Somatostatin**:
- Synthesized in the hypothalamus (part of the brain) and also produced by the pancreas (an endocrine gland).
- This hormone inhibits the release of several other hormones, including growth hormone.

Based on this analysis, the correct answer is **Somatostatin**, as it is the only option that is synthesized in both the brain (hypothalamus) and an endocrine gland (pancreas).

### Step-by-Step Solution:
1. **Identify the hormones** listed in the options.
2. **Research the synthesis locations** of each hormone:
- ACTH: Anterior pituitary gland.
- Cortisol: Adrenal glands.
- Oxytocin: Hypothalamus (brain) and posterior pituitary gland.
- Somatostatin: Hypothalamus (brain) and pancreas (endocrine gland).
3. **Compare the synthesis locations** to see which hormone is produced in both the brain and an endocrine gland.
4. **Conclude** that Somatostatin is synthesized in both the hypothalamus (brain) and the pancreas (endocrine gland).