What is the correct to say about the hormone action in humans?

Options

A. Glucagon is secreted by `beta-`cells of islets of Langerhans and stimulated glycogenolysis.
B. Secretion of thymosin is stimulated with aging.
C. In females, FSH first binds with specific receptors on ovarian cell membrane.
D. FSH stimulates the secretion of androgens.

Explanation

To determine the correct statement about hormone action in humans, we will analyze each of the provided options step by step.

### Step 1: Analyze the first statement
The first statement claims that glucagon is secreted by beta cells of the islets of Langerhans and stimulates glycogenolysis.

**Evaluation:**
- Glucagon is actually secreted by the **alpha cells** of the islets of Langerhans, not beta cells.
- Its primary function is to stimulate **gluconeogenesis** (the production of glucose) and not glycogenolysis (the breakdown of glycogen).

**Conclusion:** This statement is **incorrect**.

### Step 2: Analyze the second statement
The second statement states that the secretion of thymosine is stimulated by aging.

**Evaluation:**
- Thymosine is produced by the **thymus gland**, which tends to atrophy or degenerate with age.
- As a result, the secretion of thymosine actually becomes negligible in adults, rather than being stimulated.

**Conclusion:** This statement is **incorrect**.

### Step 3: Analyze the third statement
The third statement mentions that in females, FSH first binds with specific receptors on the ovarian cell membrane.

**Evaluation:**
- Follicle Stimulating Hormone (FSH) is indeed a proteinaceous hormone that binds to specific receptors on the target cells.
- FSH has a large molecular weight and is insoluble in lipids, which means it cannot pass through the cell membrane and must bind to **membrane-bound receptors**.

**Conclusion:** This statement is **correct**.

### Step 4: Analyze the fourth statement
The fourth statement claims that FSH stimulates the secretion of androgens.

**Evaluation:**
- FSH primarily promotes the development of ovarian follicles in females and does not stimulate the secretion of androgens.
- Androgens are typically stimulated by Luteinizing Hormone (LH) in males and females.

**Conclusion:** This statement is **incorrect**.

### Final Conclusion
The only correct statement about hormone action in humans is the third one: "In females, FSH first binds with specific receptors on ovarian cell membrane."