Study the two cases carefully, What would be the correct interpretation of the two cases ?
`{:("Case","Mother","Father","Children"),("Case I","With disease","Normal","Sons always with disease"),("Case II","With disease","Normal","Sons and daughters could show disease"):}`

Options

A. `{:("Case I : X-linked recessive disease"),("Case II : Autosomal recessive disease"):}`
B. `{:("Case I : Y-linked recessive disease"),("Case II : X-linked recessive disease"):}`
C. Case I and II : X-linked recessive disease
D. `{:("Case I : Y-linked dominant disease"),("Case II : Autosomal dominant disease"):}`

Explanation

To interpret the two cases provided in the question, we will analyze the inheritance patterns based on the information given about the parents and their children.

### Step-by-Step Solution:

1. **Understanding Case I**:
- In Case I, the mother has the disease, and the father is normal.
- The children (specifically the sons) always have the disease.
- This suggests that the disease is passed from the mother to the sons, indicating a pattern of inheritance where the mother contributes the affected allele.

2. **Identifying the Inheritance Pattern in Case I**:
- Since only the sons are affected and the father does not pass the disease to his sons, this points towards an X-linked inheritance pattern.
- In X-linked recessive diseases, males (XY) are more likely to express the disease because they have only one X chromosome. If the mother (XX) carries the disease allele on one of her X chromosomes, all her sons (XY) will inherit that X chromosome, resulting in them being affected.

3. **Understanding Case II**:
- In Case II, the mother has the disease, and the father is normal.
- Here, both sons and daughters could potentially show the disease.
- This indicates that the disease can be inherited by both sexes, suggesting a different inheritance pattern.

4. **Identifying the Inheritance Pattern in Case II**:
- The fact that both sons and daughters can show the disease means that it is likely not X-linked.
- This pattern suggests that the disease is autosomal, meaning it is located on one of the non-sex chromosomes (autosomes).
- Since both males and females can inherit the disease, it is likely an autosomal recessive condition, where both parents must carry at least one copy of the recessive allele for the children to express the disease.

5. **Conclusion**:
- Therefore, the correct interpretation is:
- **Case I**: X-linked recessive disease (sons always affected).
- **Case II**: Autosomal recessive disease (sons and daughters could show disease).

### Final Answer:
- **Case I**: X-linked recessive disease.
- **Case II**: Autosomal recessive disease.