A toxic substance, reponsible for the chills and high fever recurring every three to four days in malarial fever, is

Options

A. interferon
B. haemozion
C. hirudin
D. colostrum

Explanation

To solve the question regarding the toxic substance responsible for the chills and high fever recurring every three to four days in malarial fever, we can follow these steps:

### Step-by-Step Solution:

1. **Understand Malarial Fever**:
- Malarial fever is caused by the Plasmodium species, which are parasites that infect humans.

**Hint**: Malarial fever is linked to a specific type of parasite.

2. **Identify the Lifecycle of the Parasite**:
- The Plasmodium parasite enters the human body, travels to the liver, and multiplies there before invading red blood cells (RBCs).

**Hint**: Consider where the parasite grows and how it affects blood cells.

3. **Recognize the Effect on Red Blood Cells**:
- When the Plasmodium parasite invades the RBCs, it causes the cells to rupture. This rupture leads to the release of toxic substances into the bloodstream.

**Hint**: Think about what happens to red blood cells during malaria.

4. **Identify the Toxic Substance**:
- One of the toxic substances released during the rupture of RBCs is called hemozoin. This substance is responsible for the symptoms of chills and high fever associated with malaria.

**Hint**: Look for a substance specifically linked to the symptoms of chills and fever in malaria.

5. **Evaluate the Options**:
- The options given were interferon, hemozoin, iridine, and cholesterol. Based on the understanding that hemozoin is released during the RBC rupture, we can conclude that hemozoin is the correct answer.

**Hint**: Compare each option with the information gathered about malaria and its symptoms.

### Final Answer:
The toxic substance responsible for the chills and high fever recurring every three to four days in malarial fever is **Hemozoin**.