Study carefully the following stages of life cycle of malarial parasite i.e., Plasmodium. Arrange these stages in the correct sequence and select the correct answer.
1. Sporozoites leave the blood stream and enter the liver cells of man.
2. Sporozoites present in the salivary glands of female Anopheles mosquito are injected into the blood stream of man.
3. The parasite reproduces asexually in RBCs, resulting in bursting of RBCs and causing the cycles of fever, relased parasites infect new RBCs.
4. The parasite reproduces asexually in liver cells, ultimately causing the rupturing of cells.
5. Two types of gametocytes i.e., microgametocytes and macrogametocytes develop in the RBCs.
6. Female Anopheleles mosquito takes up the gametocytes with blood meal of an infected person.
7. Mature infective stage of the parasite i.e., sporozoites escape from intestine and migrate to the mosquito's salivary glands.
8. Fertilisation and developmental stages of the parasite take place in mosquito's stomach.

Options

A. (a) `2 to 1 to 4 to 3 to 5 to 6 to 8 to 7`
B. (b) `2 to 4 to 1 to 3 to 5 to 6 to 7 to 8`
C. (c) `1 to 2 to 4 to 3 to 5 to 6 to 8 to 7 `
D. (d) `6 to 8 to 7 to 4 to 5 to 2 to 3 to 1`

Answer

To arrange the stages of the life cycle of the malarial parasite, Plasmodium, in the correct sequence, we will follow the life cycle as described in the video transcript. Here’s the step-by-step solution:

### Step-by-Step Solution:

1. **Sporozoites present in the salivary glands of female Anopheles mosquito are injected into the bloodstream of man.**
- This is the first step when the mosquito bites a human and injects the sporozoites.

2. **Sporozoites leave the bloodstream and enter the liver cells of man.**
- After entering the bloodstream, the sporozoites migrate to the liver cells.

3. **The parasite reproduces asexually in liver cells, ultimately causing the rupturing of cells.**
- In the liver, the sporozoites undergo asexual reproduction, leading to the formation of merozoites and the rupture of liver cells.

4. **The parasite reproduces asexually in RBCs, resulting in bursting of RBCs and causing cycles of fever, releasing parasites that infect new RBCs.**
- The merozoites then enter red blood cells (RBCs), where they continue to reproduce asexually, causing the symptoms of malaria.

5. **Two types of gametocytes, i.e., microgametocytes and macrogametocytes, develop in the RBCs.**
- Some of the merozoites develop into gametocytes within the RBCs.

6. **Female Anopheles mosquito takes up the gametocytes with a blood meal of an infected person.**
- When the infected person is bitten again by a female Anopheles mosquito, the gametocytes are ingested.

7. **Fertilization and developmental stages of the parasite take place in the mosquito's stomach.**
- Inside the mosquito, the male and female gametocytes fuse to form a zygote, which undergoes further development.

8. **Mature infective stage of the parasite, i.e., sporozoites, escape from the intestine and migrate to the mosquito's salivary glands.**
- The developed sporozoites then migrate to the salivary glands of the mosquito, ready to infect another human, thus completing the cycle.

### Final Sequence:
1. 2
2. 1
3. 4
4. 3
5. 5
6. 6
7. 8
8. 7

### Correct Answer:
The correct sequence is: **2 → 1 → 4 → 3 → 5 → 6 → 8 → 7**.