Which of the following statements is not true about enzyme inhibitors ?

Options

A. Inhibit the catalytic activity of the enzyme .
B. Prevent the binding of substrate .
C. Generally a strong covalent bond is formed between an inhibitor and an enzyme.
D. Inhibitors can be competitive or non-competitive .

Explanation

To determine which statement is not true about enzyme inhibitors, we need to analyze the provided options based on our understanding of enzyme inhibitors.

### Step-by-Step Solution:

1. **Understanding Enzyme Inhibitors**:
- Enzyme inhibitors are substances that decrease or inhibit the activity of enzymes. They can bind to enzymes and prevent them from catalyzing reactions.

2. **Reviewing the Statements**:
- We need to evaluate each statement provided in the options to identify which one is incorrect.

3. **Analyzing Each Option**:
- **Option A**: "Enzyme inhibitors inhibit the catalytic activity of enzymes."
- This statement is true. Enzyme inhibitors do inhibit the activity of enzymes.

- **Option B**: "Prevent the binding of substrate."
- This statement is also true. Enzyme inhibitors can prevent substrates from binding to the active site of the enzyme.

- **Option C**: "Generally a strong covalent bond is formed between inhibitor and enzyme."
- This statement is misleading. While some enzyme inhibitors can form covalent bonds with enzymes, they can also bind through weaker, non-covalent interactions. Therefore, this statement is not universally true.

- **Option D**: "Inhibitors can be competitive and non-competitive."
- This statement is true. Inhibitors can indeed be classified as competitive (competing with the substrate for the active site) or non-competitive (binding to a different site).

4. **Conclusion**:
- The statement that is not true about enzyme inhibitors is **Option C**: "Generally a strong covalent bond is formed between inhibitor and enzyme."

### Final Answer:
The statement that is not true about enzyme inhibitors is **Option C**.

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