Drugs which bind strongly to the active site of an enzyme and do not depend upon concentration of natural substrate are called as

Options

A. competitive inhibitors
B. non-competitive inhibitors
C. `beta`-blockers.
D. `alpha`-blockers.

Answer

To solve the question, we need to identify the type of drugs that bind strongly to the active site of an enzyme and do not depend on the concentration of the natural substrate. Here’s a step-by-step breakdown of the solution:

### Step 1: Understand the Role of Enzymes
Enzymes are biological catalysts that speed up chemical reactions in the body. They have specific active sites where substrates bind to undergo a reaction.

**Hint:** Enzymes have active sites that are specific to substrates, and the binding of substrates is crucial for enzyme activity.

### Step 2: Identify Types of Inhibitors
There are different types of enzyme inhibitors:
- **Competitive Inhibitors:** These bind to the active site of the enzyme and compete with the substrate for binding.
- **Non-competitive Inhibitors:** These bind to a different site on the enzyme, not the active site, and do not compete with the substrate.
- **Uncompetitive Inhibitors:** These bind to the enzyme-substrate complex and prevent the reaction from proceeding.

**Hint:** Focus on the type of inhibitor that interacts directly with the active site of the enzyme.

### Step 3: Analyze the Given Question
The question specifies that the drugs bind strongly to the active site and do not depend on the concentration of the natural substrate. This indicates that the binding of the drug is independent of the substrate concentration, which is characteristic of competitive inhibition.

**Hint:** Consider how competitive inhibitors function in relation to substrate concentration.

### Step 4: Conclude the Answer
Based on the analysis, the drugs that bind strongly to the active site of an enzyme and do not depend on the concentration of the natural substrate are called **Competitive Inhibitors**.

**Final Answer:** Competitive Inhibitors