NIDDM is caused due to

Options

A. Deficiency of insulin
B. Destruction of beta-cells
C. Reduced in number or lack of insulin receptors on target cells
D. Deficiency of secretions from Islet of Langerhans

Answer

**Step-by-Step Solution:**

1. **Understanding NIDDM**: NIDDM stands for Non-Insulin Dependent Diabetes Mellitus. It is a form of diabetes where the body does not use insulin effectively, leading to abnormal glucose homeostasis.

2. **Identifying Causes**: To determine what causes NIDDM, we need to analyze the options provided. The key factors to consider are insulin production, insulin receptors, and the role of hormones.

3. **Evaluating Options**:
- **Option 1: Deficiency of Insulin**: This is more characteristic of Type 1 Diabetes Mellitus, where there is an absolute deficiency of insulin due to the destruction of beta cells in the pancreas.
- **Option 2: Destruction of B Cells**: This is also associated with Type 1 Diabetes, where the insulin-producing beta cells are destroyed. This does not apply to NIDDM.
- **Option 3: Reduction in the Number or Lack of Insulin Receptors**: This option is correct. In NIDDM, the body’s cells become resistant to insulin due to a decrease in the number of insulin receptors, which leads to impaired glucose uptake and increased blood glucose levels.
- **Option 4: Deficiency of Secretion from Islets of Langerhans**: While there may be some reduction in insulin secretion, this is not the primary cause of NIDDM. The problem lies more in insulin resistance rather than a lack of insulin production.

4. **Conclusion**: Based on the evaluation, the correct cause of NIDDM is the reduction in the number or lack of insulin receptors on target cells, leading to insulin resistance.

**Final Answer**: NIDDM is caused due to the reduction in the number or lack of insulin receptors on target cells.

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