Which of the following statement regarding entry of HIV into target cell is/are correct?
A. The initial binding event occurs between viral Gp120 and CD, molecules.
B. It belongs to genus Flavivirus.
C. Viral entry proceeds through fusion of viral envelop with the target cell membrane .
D. Only reverse transcriptase gain entry inside the target cell

Options

A. A and B
B. B and C
C. C and D
D. A and C

Answer

To determine which statements regarding the entry of HIV into target cells are correct, let's analyze each option step by step:

### Step 1: Analyze Statement A
**Statement A:** The initial binding event occurs between viral Gp120 and CD molecules.

- **Explanation:** HIV primarily targets T-cells, which express CD4 molecules on their surface. The viral glycoprotein Gp120 binds to these CD4 molecules, initiating the infection process.
- **Conclusion:** This statement is **correct**.

### Step 2: Analyze Statement B
**Statement B:** It belongs to genus Flavivirus.

- **Explanation:** HIV is classified under the genus Retrovirus, not Flavivirus. Flavivirus includes viruses like dengue and Zika, which are different from HIV.
- **Conclusion:** This statement is **incorrect**.

### Step 3: Analyze Statement C
**Statement C:** Viral entry proceeds through fusion of viral envelope with the target cell membrane.

- **Explanation:** After the initial binding of Gp120 to CD4, a conformational change occurs that allows the viral envelope to fuse with the host cell membrane, facilitating entry of the viral contents into the cell.
- **Conclusion:** This statement is **correct**.

### Step 4: Analyze Statement D
**Statement D:** Only reverse transcriptase gains entry inside the target cell.

- **Explanation:** While reverse transcriptase is crucial for converting viral RNA into DNA, other viral proteins and enzymes also enter the host cell during the infection process. Therefore, it is incorrect to state that only reverse transcriptase enters.
- **Conclusion:** This statement is **incorrect**.

### Final Conclusion
Based on the analysis:
- **Correct Statements:** A and C
- **Incorrect Statements:** B and D

Thus, the correct answer is that statements A and C are correct regarding the entry of HIV into target cells.

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