Which of the following is not true w.r.t. HIV?

Options

A. Reverse transcription results in production of a double stranded DNA copy of the viral genome
B. ELISA is used as a confirmatory test to determine if a person is infected with HIV.
C. It is a retrovirus
D. It belongs to genus Lentivirus.

Answer

To determine which statement is not true with respect to HIV, we can analyze the provided options step by step:

### Step 1: Understanding HIV
HIV stands for Human Immunodeficiency Virus. It is a virus that attacks the immune system, specifically targeting CD4 cells (T cells), which are crucial for the immune response. If untreated, HIV can lead to AIDS (Acquired Immunodeficiency Syndrome), a condition where the immune system is severely compromised.

**Hint:** Remember that HIV is primarily known for its impact on the immune system and its progression to AIDS.

### Step 2: Analyzing the Statements
1. **Reverse transcription results in the production of a double-stranded DNA copy of the viral genome.**
- This statement is true. HIV is an RNA virus, and upon entering a host cell, it uses an enzyme called reverse transcriptase to convert its RNA into double-stranded DNA.

**Hint:** Focus on the process of reverse transcription, which is a key characteristic of retroviruses like HIV.

2. **ELISA is used as a confirmatory test to determine if a person is infected with HIV.**
- This statement is not true. ELISA (Enzyme-Linked Immunosorbent Assay) is a screening test for HIV, not a confirmatory test. While it can indicate the presence of antibodies against HIV, confirmatory tests (like Western Blot or PCR) are needed to definitively diagnose HIV infection.

**Hint:** Distinguish between screening tests and confirmatory tests in the context of HIV diagnosis.

3. **It is a retrovirus.**
- This statement is true. HIV is classified as a retrovirus because it replicates in a host cell by converting its RNA into DNA.

**Hint:** Recall the classification of HIV as a retrovirus and its unique replication mechanism.

4. **It belongs to the genus Lentivirus.**
- This statement is also true. HIV is part of the Lentivirus genus, which includes other viruses that cause chronic diseases in animals and humans.

**Hint:** Remember that the genus classification helps in understanding the characteristics of the virus.

### Conclusion
After analyzing all the statements, the one that is not true regarding HIV is the second statement about ELISA being a confirmatory test.

### Final Answer
The statement that is not true with respect to HIV is: **"ELISA is used as a confirmatory test to determine if a person is infected with HIV."**