All are neurotropic (involving central nervous system) viral diseases except

Options

A. Rabies
B. poliomyelitis
C. Encephalitis
D. Herpes simplex

Answer

To solve the question regarding which viral disease does not involve the central nervous system (CNS), we will analyze each option provided:

1. **Understanding Neurotropic Diseases**:
- Neurotropic diseases are those that affect the nervous system, particularly the brain and spinal cord.

2. **Analyzing Each Option**:
- **Option A: Rabies**
- Rabies is caused by the rabies virus and primarily affects the brain and central nervous system. It is a neurotropic disease.
- **Option B: Poliomyelitis**
- Poliomyelitis, caused by the poliovirus, affects the nervous system and can lead to paralysis. It is also a neurotropic disease.
- **Option C: Encephalitis**
- Encephalitis refers to inflammation of the brain, which is often caused by viral infections. This condition directly involves the central nervous system, making it neurotropic.
- **Option D: Herpes Simplex**
- Herpes simplex virus causes sores and blisters, primarily around the mouth and genitals. While it can affect the nervous system in certain cases (like herpes simplex encephalitis), it primarily does not involve the CNS in its common form.

3. **Conclusion**:
- Among the options provided, herpes simplex is the disease that does not primarily involve the central nervous system in its typical presentation. Therefore, the correct answer is **Option D: Herpes Simplex**.