Vaccination against smallpox was developed by:

Options

A. Edward Jenner
B. Louis Pasteur
C. Alexander Flemming
D. Robert Koch

Answer

**Step-by-Step Solution:**

1. **Identify the Question**: The question asks who developed the vaccination against smallpox.

2. **List the Options**: The options provided are:
- A) Edward Jenner
- B) Louis Pasteur
- C) Alexander Fleming
- D) Robert Koch

3. **Evaluate Each Option**:
- **Edward Jenner**: He was a British doctor known for developing the smallpox vaccination in 1796. He observed that milkmaids who had cowpox (a less severe disease) seemed to be immune to smallpox. This observation led him to create the first successful vaccine.
- **Louis Pasteur**: He was a renowned microbiologist known for his work on microbial fermentation and pasteurization. He did not develop the smallpox vaccine.
- **Alexander Fleming**: He was a bacteriologist famous for discovering penicillin, an antibiotic, but he did not work on smallpox vaccination.
- **Robert Koch**: He was a bacteriologist known for his postulates in studying bacteria and identifying the causative agents of diseases like tuberculosis and cholera, but he did not develop the smallpox vaccine.

4. **Determine the Correct Answer**: Based on the evaluations, the correct answer is **Edward Jenner**, as he was the one who developed the vaccination against smallpox.

5. **Final Answer**: The vaccination against smallpox was developed by **Edward Jenner**.

---