High temperature in malaria occurs after completion of

Options

A. erythrocytic cycle
B. exo-erythrocytic cycle
C. pre-erythrocytic cycle
D. gametogony

Answer

To solve the question regarding when high temperature occurs in malaria, we need to understand the life cycle of the malaria parasite, specifically focusing on the cycles mentioned in the options.

### Step-by-Step Solution:

1. **Understanding the Life Cycle of Malaria**:
- The malaria parasite, primarily *Plasmodium*, is transmitted to humans through the bite of an infected Anopheles mosquito.

2. **Identifying the Stages**:
- The life cycle of *Plasmodium* includes several stages:
- **Sporozoites**: These are the forms of the parasite that enter the human bloodstream when a mosquito bites.
- **Exo-erythrocytic Cycle**: This occurs when sporozoites migrate to the liver and multiply. This stage does not cause fever.
- **Erythrocytic Cycle**: After multiplying in the liver, the parasites (now merozoites) enter the red blood cells (RBCs) and continue to multiply. This stage is crucial as it leads to the rupture of RBCs.

3. **Symptoms of Malaria**:
- The high temperature (fever) associated with malaria is primarily due to the rupture of RBCs during the erythrocytic cycle. When the RBCs burst, they release toxins and hemozoin, which trigger the immune response, leading to fever and chills.

4. **Analyzing the Options**:
- **Erythrocytic Cycle**: This is when the high temperature occurs due to the destruction of RBCs.
- **Exo-erythrocytic Cycle**: This stage occurs in the liver and does not cause fever.
- **Pre-erythrocytic Gametogony**: This involves the formation of gametes and is not directly related to the fever symptoms.

5. **Conclusion**:
- Therefore, the high temperature in malaria occurs after the completion of the **erythrocytic cycle**.

### Final Answer:
High temperature in malaria occurs after the completion of the **erythrocytic cycle**.

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