Which one of the following mammalian cells is not capable of metabolising glucose to carbon-dioxide aerobically ?

Options

A. Unstriated muscle cells
B. Liver cells
C. Red blood cells
D. White blood cells

Answer

To solve the question "Which one of the following mammalian cells is not capable of metabolizing glucose to carbon-dioxide aerobically?", we will analyze the options provided and understand the metabolic capabilities of each cell type.

### Step-by-Step Solution:

1. **Understanding Aerobic Metabolism**:
- Aerobic metabolism refers to the process of producing cellular energy in the presence of oxygen. This process typically involves glycolysis, the Krebs cycle, and oxidative phosphorylation, which occurs in the mitochondria.

2. **Analyzing the Options**:
- **Option 1: Unstriated Muscle Cells**:
- These cells can perform aerobic respiration as they contain mitochondria and can metabolize glucose to carbon dioxide when oxygen is available.
- **Option 2: Liver Cells**:
- Liver cells (hepatocytes) also have mitochondria and are capable of aerobic respiration, metabolizing glucose to carbon dioxide.
- **Option 3: Red Blood Cells (RBCs)**:
- Red blood cells lack mitochondria and therefore cannot perform aerobic respiration. They primarily rely on anaerobic metabolism (fermentation) to generate energy.
- **Option 4: White Blood Cells**:
- White blood cells can perform aerobic respiration as they contain mitochondria and can metabolize glucose to carbon dioxide.

3. **Conclusion**:
- Based on the analysis, the mammalian cell that is not capable of metabolizing glucose to carbon dioxide aerobically is the **Red Blood Cells (RBCs)**.

### Final Answer:
**Red Blood Cells (RBCs)** are not capable of metabolizing glucose to carbon dioxide aerobically.