If you suspect major deficiency of antibodies in a person, to which of the following would you look for confirmatory evidence

Options

A. Serum globulins
B. Fibrinogen in the plasma
C. Haemocytes
D. Serum albumins

Answer

To determine if there is a major deficiency of antibodies in a person, follow these steps:

### Step-by-Step Solution:

1. **Understand Antibodies**: Recognize that antibodies are proteins produced by the immune system to neutralize pathogens. They are also known as immunoglobulins.

2. **Identify the Role of Serum Globulins**: Know that antibodies belong to the class of proteins called globulins, specifically gamma globulins. These make up about 17-20% of the total protein content in blood serum.

3. **Recognize the Importance of Testing**: When suspecting a deficiency of antibodies, it is crucial to measure the levels of serum globulins. A low level of serum globulins would indicate a deficiency in antibodies.

4. **Evaluate the Options**:
- **A. Serum globulins**: This is the correct choice as it directly relates to the measurement of antibodies.
- **B. Fibrinogen in the plasma**: This is involved in blood clotting, not antibody production.
- **C. Hemocytes**: These are blood cells, but they do not directly measure antibody levels.
- **D. Serum albumins**: These are proteins that help maintain osmotic pressure in the blood, not related to antibodies.

5. **Conclusion**: Based on the understanding of antibodies and the function of serum globulins, the confirmatory evidence for a major deficiency of antibodies would be found in the measurement of serum globulins.

### Final Answer:
The correct answer is **A. Serum globulins**.

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