Which statement is wrong for Krebs' cycle ?

Options

A. There are three points in the cycle where `NAD^+` is reduced to `NADH+H^+`
B. There is one point in the cycle where `FAD^+` is reduced to `FADH_2`
C. During conversion of succinyl CoA to succinic acid, a molecule of GTP is synthesized
D. The cycle starts with condensation of acetyl group (acetyl CoA) with pyruvic acid to yield citric acid

Answer

To determine which statement is wrong regarding the Krebs cycle, we will analyze each statement provided in the question.

### Step-by-Step Solution:

1. **Analyze Statement A**:
- The statement claims that there are three points in the cycle where NAD+ is reduced to NADH + H+.
- **Evaluation**: This is correct. In the Krebs cycle, NAD+ is indeed reduced to NADH at three different steps.

2. **Analyze Statement B**:
- The statement claims that there is one point in the cycle where FAD+ is reduced to FADH2.
- **Evaluation**: This is also correct. FAD+ is reduced to FADH2 at one specific step in the Krebs cycle.

3. **Analyze Statement C**:
- The statement claims that during the conversion of succinyl coenzyme A to succinic acid, a molecule of GTP is synthesized.
- **Evaluation**: This statement is correct. The conversion of succinyl coenzyme A to succinate does indeed produce GTP.

4. **Analyze Statement D**:
- The statement claims that the cycle starts with the condensation of acetyl group (acetyl coenzyme A) with pyruvic acid to yield citric acid.
- **Evaluation**: This statement is incorrect. The Krebs cycle actually starts with the condensation of acetyl coenzyme A with oxaloacetic acid to yield citric acid, not pyruvic acid.

### Conclusion:
The wrong statement regarding the Krebs cycle is **Statement D**.

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