Which of these statements is incorrect.

Options

A. Oxidative phosphorylation takes place in outer mitochondrial membrane
B. Glycolysis operates as long as it is supplied with NAD that can pick up hydrogen atoms.
C. Glycolysis occurs in cytosol.
D. Enzymes of TCA cycle are present in mitochondrial matrix.

Answer

To determine which statement is incorrect, we will analyze each statement provided in the question step by step.

### Step 1: Analyze the first statement
- **Statement**: "Oxidative phosphorylation takes place in the outer mitochondrial membrane."
- **Analysis**: This statement is incorrect because oxidative phosphorylation occurs in the inner mitochondrial membrane, not the outer membrane.

### Step 2: Analyze the second statement
- **Statement**: "Glycolysis operates as long as it is supplied with NAD that can pick up the hydrogen atoms."
- **Analysis**: This statement is correct. Glycolysis requires NAD+ to accept electrons (in the form of hydrogen atoms) during the oxidation of glucose to produce pyruvate.

### Step 3: Analyze the third statement
- **Statement**: "Glycolysis occurs in the cytosol."
- **Analysis**: This statement is also correct. Glycolysis takes place in the cytosol of the cell.

### Step 4: Analyze the fourth statement
- **Statement**: "Enzymes of TCA cycle are present in mitochondrial matrix."
- **Analysis**: This statement is correct as well. The enzymes of the TCA cycle (Krebs cycle) are located in the mitochondrial matrix, with the exception of succinate dehydrogenase, which is associated with the inner mitochondrial membrane.

### Conclusion
After analyzing all the statements:
- The incorrect statement is **Statement 1**: "Oxidative phosphorylation takes place in the outer mitochondrial membrane."

### Final Answer
The correct answer is **Option A** (the first statement is incorrect).

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