In which conditon oxygen dissociation curve of haemoglobin shift to right of normal curve ?

Options

A. decrease in pH
B. decrease in acidity
C. decrease in temperature
D. decrese in `co_(2)` concentration

Answer

To determine the conditions under which the oxygen dissociation curve of hemoglobin shifts to the right of the normal curve, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding the Oxygen Dissociation Curve**:
- The oxygen dissociation curve illustrates how readily hemoglobin binds to and releases oxygen at different partial pressures of oxygen (pO2).
- The curve is typically sigmoid in shape, indicating that hemoglobin's affinity for oxygen changes with varying pO2 levels.

2. **Identifying Factors Affecting the Curve**:
- Several physiological factors can influence the position of the oxygen dissociation curve, including pH, temperature, and carbon dioxide concentration.

3. **Rightward Shift of the Curve**:
- A rightward shift in the oxygen dissociation curve indicates that hemoglobin has a decreased affinity for oxygen, meaning it releases oxygen more readily.
- This shift occurs under certain conditions, such as:
- **Increased temperature**: Higher temperatures promote oxygen release.
- **Decreased pH (increased acidity)**: A lower pH (more acidic conditions) leads to a rightward shift. This is often due to increased carbon dioxide levels, which produce carbonic acid.
- **Increased carbon dioxide concentration**: More CO2 in the blood results in more H+ ions, lowering pH and facilitating oxygen release.

4. **Conclusion**:
- The correct condition that causes the oxygen dissociation curve of hemoglobin to shift to the right is a **decrease in pH (increased acidity)**, which is often associated with increased carbon dioxide concentration and higher temperatures.

### Final Answer:
The oxygen dissociation curve of hemoglobin shifts to the right under conditions of **decreased pH (increased acidity)**, which can occur during exercise or increased metabolic activity.

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